The effectiveness of erectile dysfunction Fildena 200 is based on their ability to increase libido. Sildenafil is a phosphodiesterase inhibitor that enhances the effect of NO. This substance is also metabolize by cytochrome P450 3A4 and 2C9.
Sildenafil is a phosphodiesterase inhibitor
Sildenafil is a phosphodiesterase inhibitor (PDE) that has been use for treating erectile dysfunction in men for over five years. This drug was initially develope as an antianginal Fildena 100 but was later found to be more effective for treating erectile dysfunction. It has since been use to treat pulmonary arterial hypertension and pulmonary arterial disfunction in both men and women. Sildenafil is also use to treat pulmonary arterial hypertension and is one of the few PDE5 inhibitors available on the market today. It works by blocking PDE5 enzymes in the heart and arteries in the penis, opening up narrowed arteries to improve erection.
PDE5 is one of the main players in retinal diseases. Disruption of cGMP levels in the retina affects photoreceptor survival. PDE5 inhibitors are often use in the treatment of ED and PAH. Sildenafil inhibits both PDE5 and PDE6. It is important to note that sildenafil has the same effect on both PDE5 and PDE6.
It enhances the effect of NO
Sildenafil, a drug used for erectile dysfunction, inhibits the production of iROS, the product of LPS, in macrophages. The drug also reduces iROS production by MAPKs, which potently suppress the production of NADPH. These findings suggest that sildenafil may enhance the effect of NO, a naturally occurring molecule, in the body.
The mechanism by which sildenafil enhances the effect of NO is unclear. It is thought to inhibit platelet thrombus formation and may also have a dilating effect on peripheral arterial-venous systems.
It inhibits cGMP-specific phosphodiesterase
Sildenafil citrate is a prescription drug that selectively inhibits phosphodiesterase type 5 (PDE-5), a key enzyme in the cGMP signaling cascade. By inhibiting PDE-5, it can improve erectile function and restore the erectile response to sexual stimulation. It is well tolerate and quickly absorbe with a terminal half-life of three to five hours. It is also prove effective in treating erectile dysfunction (ED).
PDEs can be classified into seven classes, and there are numerous subtypes. The enzymes are distribute throughout the body and their activities vary in different tissues. All PDEs are characterize by their ability to lower intracellular levels of cyclic nucleotides such as cGMP and cyclic guanosine monophosphate.
It is metabolize by cytochrome P450 3A4 and 2C9
Viagra and other male erectile dysfunction drugs have made the lives of many men easier. However, the use of these drugs should be accompanied by medical care, as they have the potential to cause cardiovascular side effects. Sildenafil citrate is one such drug which is contraindicate in men with cardiovascular disease. However it is often use for recreational purposes. In order to make a relationship stronger the use of this drug should be limit in men with cardiovascular disease.
The researchers conducted a facility-based cross-sectional study in Gondar, Ethiopia, a town located 738 kilometers from the capital Addis Ababa. The town has an estimated population of 249,851 residents in 2007; the male to female ratio is approximately 1.5:1. The study participants were recruite from seven community pharmacies and were interview about their use of sildenafil citrate.
It is contraindicate in as many as 6 million patients
Although a drug like Sildenafil can improve erectile function and sexual performance it is also associate with a number of adverse events such as heart failure. In addition to the cardiovascular risks sildenafil has also been linke to a number of ocular complications. These include central serous chorioretinopathy, serous macular detachment, and ventricular arrhythmia. In addition it has also been linke to a higher risk of developing a form of vascular disease such as cerebral ischemia in patients taking sildenafil.
As a result sildenafil should be use with caution in patients with stable coronary artery disease. The drug is contraindicate in people with mild to moderate coronary artery disease as it can cause life-threatening hypotension. Regardless of age or other medical conditions patients with a history of heart disease should discuss the benefits and risks of taking sildenafil with their physician before commencing treatment.
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